Nrcam^m1J
Spontaneous Allele Detail

Summary

• Symbol: Nrcam^m1J
• Name: neuronal cell adhesion molecule; mutation 1, The Jackson Laboratory
• MGI ID: MGI:5444298
• Gene: Nrcam Location: Chr12:44375668-44648747 bp, + strand Genetic Position: Chr12, 20.71 cM
• Alliance: Nrcam^m1J page

Mutation origin

• Strain of Origin: B6.129P2-Cnr2^tm1Dgen/J

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutations: Duplication, Insertion
• Mutation details: This 259 bp insertion of a B2 element into exon 26 with a duplication of the flanking 15 bp of the exon introduced in two premature stop codons, which terminate translation before the transmembrane domain. Western blot and immunolabeling both failed to detect the protein.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrcam Mutation: 87 strains or lines available

References

• Original: J:240096 Morelli KH, et al., Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes. Cell Rep. 2017 Mar 28;18(13):3178-3191
• All: 2 reference(s)