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Hsd11b1tm1Ggla
Targeted Allele Detail
Summary
Symbol: Hsd11b1tm1Ggla
Name: hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1, Gareth Lavery
MGI ID: MGI:5444438
Synonyms: 11beta-HSD1fl
Gene: Hsd11b1  Location: Chr1:192903917-192946345 bp, - strand  Genetic Position: Chr1, 97.67 cM
Alliance: Hsd11b1tm1Ggla page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:189132
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 5. (J:189132)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsd11b1 Mutation:  28 strains or lines available
References
Original:  J:189132 Semjonous NM, et al., Hexose-6-phosphate dehydrogenase contributes to skeletal muscle homeostasis independent of 11beta-hydroxysteroid dehydrogenase type 1. Endocrinology. 2011 Jan;152(1):93-102
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory