Map2k7^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Map2k7^tm1Pngr
• Name: mitogen-activated protein kinase kinase 7; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:5444459
• Synonyms: mkk7^neo
• Gene: Map2k7 Location: Chr8:4288740-4297897 bp, + strand Genetic Position: Chr8, 1.99 cM, cytoband A1.1
• Alliance: Map2k7^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188339
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Part of exon 9 including the site of activating phosphorylation was replaced with a neo cassette in the inverse orientation via homologous recombination. (J:83279)

Generation of the Map2k7^tm1Pngr allele

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map2k7 Mutation: 20 strains or lines available

References

• Original: J:83279 Kishimoto H, et al., Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem. 2003 May 9;278(19):16595-601
• All: 5 reference(s)