Tg(tetO-IL1B)KBry
Transgene Detail

Summary

• Symbol: Tg(tetO-IL1B)KBry
• Name: transgene insertion K, Kristina Bry
• MGI ID: MGI:5444502
• Synonyms: (tetO)7CMV-hIL-1beta
• Transgene: Tg(tetO-IL1B)KBry Location: unknown
• Alliance: Tg(tetO-IL1B)KBry page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-IL1B)KBry expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL1B (3553)

  Il1b	(MGI:96543)

• Mutation details: This transgene contains the human IL1B cDNA coding for the active, mature protein which was inserted between seven copies of the tetracycline Operator (tetO)7-CMV minimal promoter and the bovine growth factor polyadenylation signals sequence. TetO, when present in cells also carrying a tetracycline transactivator (tTA) or reverse transactivator (rtTA) transgene, is inactivated or activated, respectively, by the administration of tetracycline or its analog doxycycline. Three lines were made (K,L, and M) with line K showing highest human IL1B levels. (J:107601)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Bronchopulmonary dysplasia (J:130523).

References

• Original: J:107601 Lappalainen U, et al., Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung. Am J Respir Cell Mol Biol. 2005 Apr;32(4):311-8
• All: 8 reference(s)