Zbtb46^{tm1(HBEGF)Mnz}
Targeted Allele Detail

Summary

• Symbol: Zbtb46^{tm1(HBEGF)Mnz}
• Name: zinc finger and BTB domain containing 46; targeted mutation 1, Michel C Nussenzweig
• MGI ID: MGI:5444842
• Synonyms: Zbtb46^DTR, Zbtb46^tm1(DTR)Mnz, zDC-DTR
• Gene: Zbtb46 Location: Chr2:181029555-181101219 bp, - strand Genetic Position: Chr2, 103.63 cM, cytoband H4
• Alliance: Zbtb46^{tm1(HBEGF)Mnz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189122
• Parent Cell Line: CY2.4 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Zbtb46^{tm1(HBEGF)Mnz} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: An IRES and human diphtheria toxin receptor (HBEGF) fused with mCherry was inserted downstream of the stop codon. Flow cytometry failed to detect expression of mCherry. (J:189122)

Generation of the Zbtb46^{tm1(HBEGF)Mnz} knock-in allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zbtb46 Mutation: 36 strains or lines available

References

• Original: J:189122 Meredith MM, et al., Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med. 2012 Jun 4;209(6):1153-65
• All: 48 reference(s)