Tg(KRT14-Prss8)1Hum
Transgene Detail

Summary

• Symbol: Tg(KRT14-Prss8)1Hum
• Name: transgene insertion 1, Edith Hummler
• MGI ID: MGI:5444854
• Transgene: Tg(KRT14-Prss8)1Hum Location: unknown Genetic Position: ChrY, Syntenic
• Alliance: Tg(KRT14-Prss8)1Hum page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Prss8)1Hum expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prss8 (MGI:1923810)

• Mutation details: A mouse Prss8 cDNA was placed under the control of the human KRT14 promoter. Only two out of five founders were fertile and able to be used to produce stable lines. Only males of this line (all males) express this transgene indicating insertion on the Y chromosome. (J:189278)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:189278 Frateschi S, et al., PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nat Commun. 2011 Jan 18;2:161
• All: 1 reference(s)