Gpr68^tm1.1Aha
Targeted Allele Detail

Summary

• Symbol: Gpr68^tm1.1Aha
• Name: G protein-coupled receptor 68; targeted mutation 1.1, Akihiro Harada
• MGI ID: MGI:5445001
• Synonyms: OGR1^null
• Gene: Gpr68 Location: Chr12:100842941-100874457 bp, - strand Genetic Position: Chr12, 51.1 cM
• Alliance: Gpr68^tm1.1Aha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189192
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette containing a bcl2 splice acceptor (SA) and a FRT-flanked beta-geo gene was inserted into the PvuII site upstream of exon 2. A loxP site was included upstream of the cassette and another loxP site was inserted into the BglII site in intron 3. Cre-mediated recombination removed the beta-geo reporter and exon 2. (J:189192)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr68 Mutation: 25 strains or lines available

References

• Original: J:189192 Nakakura T, et al., Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion. Endocrinology. 2012 Sep;153(9):4171-80
• All: 5 reference(s)