St3gal6^tm1.1Jxm
Targeted Allele Detail

Summary

• Symbol: St3gal6^tm1.1Jxm
• Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 6; targeted mutation 1.1, Jamey Marth
• MGI ID: MGI:5445089
• Synonyms: St3gal6^delta
• Gene: St3gal6 Location: Chr16:58290105-58344614 bp, - strand Genetic Position: Chr16, 34.58 cM, cytoband C1.1
• Alliance: St3gal6^tm1.1Jxm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189086
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and exon 3. RT-PCR confirmed the absence of transcript expression. (J:189086)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any St3gal6 Mutation: 21 strains or lines available

References

• Original: J:189086 Yang WH, et al., Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands. Blood. 2012 Aug 2;120(5):1015-26
• All: 3 reference(s)