Mfn2^tm1.1Mzhe
Targeted Allele Detail

Summary

• Symbol: Mfn2^tm1.1Mzhe
• Name: mitofusin 2; targeted mutation 1.1, Ming Zheng
• MGI ID: MGI:5445195
• Synonyms: MFN2^f
• Gene: Mfn2 Location: Chr4:147958056-147989161 bp, - strand Genetic Position: Chr4, 78.56 cM
• Alliance: Mfn2^tm1.1Mzhe page

Autophagosome accumulation in Mfn2^tm1.1Mzhe/Mfn2^tm1.1Mzhe Myl2^tm1(cre)Krc/Myl2⁺ hearts

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188865
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Exon 4 was floxed. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:188865)

Generation of the Mfn2^tm1.1Mzhe allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mfn2 Mutation: 27 strains or lines available

References

• Original: J:188865 Zhao T, et al., Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes. J Biol Chem. 2012 Jul 6;287(28):23615-25
• All: 1 reference(s)