Nlrc5^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Nlrc5^tm1Itl
• Name: NLR family, CARD domain containing 5; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:5445207
• Gene: Nlrc5 Location: Chr8:95160984-95253900 bp, + strand Genetic Position: Chr8, 46.55 cM
• Alliance: Nlrc5^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188857
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neo cassette replaced exons 3 and 4, which encode a portion of the CARD-like domain and the entire NBD domain. (J:188857)

Generation of the Nlrc5^tm1Itl allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc5 Mutation: 67 strains or lines available

References

• Original: J:188857 Robbins GR, et al., Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins. J Biol Chem. 2012 Jul 13;287(29):24294-303
• All: 2 reference(s)