b2b1432Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b1432Clo
• Name: Mutant line 1432; Bench to Bassinet Program (B2B/CVDC), mutation 1432 Cecilia Lo
• MGI ID: MGI:5445346
• Synonyms: Hermey
• Gene: b2b1432Clo Location: unknown
• Alliance: b2b1432Clo page

Mutant 1432-005-LA displays slightly narrow aorta and hypoplastic left ventricle.

Show the 13 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, b2b1432Clo, and may be present in stocks carrying this mutation.

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any b2b1432Clo Mutation: 0 strains or lines available

Notes

Summative Diagnosis:
Cardiovascular phenotype: Hypoplastic left ventricle, hypoplastic mitral valve, and dysplastic aortic valve with critical aortic stenosis
Noncardiovascular phenotype: Short snout

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0300	Hypoplastic left heart syndrome
1400	Aortic valve abnormality
1410	Aortic stenosis
1515	Hypoplastic mitral valve
1811	Hypoplastic left ventricle (subnormal cavity volume)
4906	Non-cardiac abnormality

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 3 reference(s)