Odad3b2b1885Clo
Chemically induced Allele Detail
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Symbol: |
Odad3b2b1885Clo |
Name: |
outer dynein arm docking complex subunit 3; Bench to Bassinet Program (B2B/CVDC), mutation 1885 Cecilia Lo |
MGI ID: |
MGI:5445347 |
Synonyms: |
Snowball |
Gene: |
Odad3 Location: Chr9:21901167-21913930 bp, - strand Genetic Position: Chr9, 8.01 cM, cytoband A4
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Alliance: |
Odad3b2b1885Clo page
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Mutant 1885-003-LA displays situs inversus totalis
Show the 6 phenotype image(s) involving this allele.
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Strain of Origin: |
C57BL/6J
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Project Collection: |
B2B/CvDC
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Allele Type: |
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Chemically induced (ENU) |
Mutation: |
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Single point mutation
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Mutation details: This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to C substitution at nucleotide +2 following coding nucleotide 828 (c.828+2T>C, NM_029939) in intron 6. This changes splice donor site G-GT to G-GC (which is assumed to be less efficient)
(J:175213)
Additional
incidental mutations
were detected in sequencing for the causative mutation,
Odad3b2b1885Clo, and may be present in stocks carrying this mutation.
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View phenotypes and curated references for all genotypes (concatenated display).
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Summative Diagnosis:
Cardiac phenotype: Dextrocardia associated with situs inversus totalis
Noncardiac phenotype: Hypoplastic spleen, adrenal anomaly, immotile/dyskinetic tracheal airway cilia
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