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Odad3b2b1885Clo
Chemically induced Allele Detail
Summary
Symbol: Odad3b2b1885Clo
Name: outer dynein arm docking complex subunit 3; Bench to Bassinet Program (B2B/CVDC), mutation 1885 Cecilia Lo
MGI ID: MGI:5445347
Synonyms: Snowball
Gene: Odad3  Location: Chr9:21901167-21913930 bp, - strand  Genetic Position: Chr9, 8.01 cM, cytoband A4
Alliance: Odad3b2b1885Clo page
Mutant 1885-003-LA displays situs inversus totalis

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to C substitution at nucleotide +2 following coding nucleotide 828 (c.828+2T>C, NM_029939) in intron 6. This changes splice donor site G-GT to G-GC (which is assumed to be less efficient) (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Odad3b2b1885Clo, and may be present in stocks carrying this mutation.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Odad3 Mutation:  27 strains or lines available
Notes
Summative Diagnosis:
Cardiac phenotype: Dextrocardia associated with situs inversus totalis
Noncardiac phenotype: Hypoplastic spleen, adrenal anomaly, immotile/dyskinetic tracheal airway cilia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0100 Situs inversus totalis
0110 Dextrocardia
4851 Kartagener syndrome (siewart syndrome)(primary ciliary dyskinesia)

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory