Thbd^tm1.1Hlwu
Targeted Allele Detail

Summary

• Symbol: Thbd^tm1.1Hlwu
• Name: thrombomodulin; targeted mutation 1.1, Hua-Lin Wu
• MGI ID: MGI:5445362
• Synonyms: TM^flox
• Gene: Thbd Location: Chr2:148246391-148250108 bp, - strand Genetic Position: Chr2, 73.45 cM
• Alliance: Thbd^tm1.1Hlwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188879
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The coding exon was flanked by a loxP site and an FRT-flanked neo cassette with a 3' loxP site. Flp-mediated recombination remvoed the neo cassette and left the gene floxed. (J:188879)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thbd Mutation: 25 strains or lines available

References

• Original: J:188879 Ma CY, et al., Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response. J Immunol. 2012 Jun 15;188(12):6328-37
• All: 1 reference(s)