Cyp4f14^tm1Rspk
Targeted Allele Detail

Summary

• Symbol: Cyp4f14^tm1Rspk
• Name: cytochrome P450, family 4, subfamily f, polypeptide 14; targeted mutation 1, Robert S Parker
• MGI ID: MGI:5445372
• Gene: Cyp4f14 Location: Chr17:33124044-33136316 bp, - strand Genetic Position: Chr17, 17.98 cM
• Alliance: Cyp4f14^tm1Rspk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188849
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: An IRES, lacZ and neo cassette was inserted downstream of exon 1. RT-PCR confirmed the absence of transcript expression in the liver. (J:188849)

Generation of the Cyp4f14^tm1Rspk allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp4f14 Mutation: 29 strains or lines available

References

• Original: J:188849 Bardowell SA, et al., Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism. J Biol Chem. 2012 Jul 27;287(31):26077-86
• All: 2 reference(s)