A4galt^tm1.1Poru
Targeted Allele Detail

Summary

• Symbol: A4galt^tm1.1Poru
• Name: alpha 1,4-galactosyltransferase; targeted mutation 1.1Poru>
• MGI ID: MGI:5445373
• Synonyms: Gb3S^-
• Gene: A4galt Location: Chr15:83110923-83135930 bp, - strand Genetic Position: Chr15, 39.4 cM
• Alliance: A4galt^tm1.1Poru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189359
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced witha loxP flanked neomycin selection cassette. The deleted sequence extended from 83,057,694 to 83,059,066 (Build 37 coordinates). The selection cassette was subsequently removed by cre mediated excision. (J:189359)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any A4galt Mutation: 61 strains or lines available

References

• Original: J:189359 Porubsky S, et al., Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells. J Immunol. 2012 Sep 15;189(6):3007-17
• All: 3 reference(s)