Tg(Prnp-FUS)WT3Cshw
Transgene Detail

Summary

• Symbol: Tg(Prnp-FUS)WT3Cshw
• Name: transgene insertion WT3, Christopher Shaw
• MGI ID: MGI:5445385
• Synonyms: hFUS, PrP-hFUS line WT3, PrP-hFUS-WT3
• Transgene: Tg(Prnp-FUS)WT3Cshw Location: unknown
• Alliance: Tg(Prnp-FUS)WT3Cshw page

Transgene origin

• Strain of Origin: (C57BL/6 x Crl:CD-1(ICR))F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-FUS)WT3Cshw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FUS (2521)

  Fus	(MGI:1353633)

• Mutation details: The transgene was designed to have the mouse prion protein promoter sequences (from vector MoPrp.Xho) and a human wild-type Fused in sarcoma (FUS) cDNA sequence with N-terminal hemagglutinin-tag (HA-hFUS). Three founders were established, including line WT3. (J:189360)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:189360 Mitchell JC, et al., Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion. Acta Neuropathol. 2013 Feb;125(2):273-88
• All: 9 reference(s)