Insl5^tm1Imad
Targeted Allele Detail

Summary

• Symbol: Insl5^tm1Imad
• Name: insulin-like 5; targeted mutation 1, Ibrahim M Adham
• MGI ID: MGI:5445709
• Gene: Insl5 Location: Chr4:102875069-102884039 bp, - strand Genetic Position: Chr4, 47.27 cM, cytoband C5-C7
• Alliance: Insl5^tm1Imad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189146
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 2. Northern blot and RT-PCR analysis confirmed the absence of transcript expression in the rectum. (J:189146)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insl5 Mutation: 14 strains or lines available

References

• Original: J:189146 Burnicka-Turek O, et al., INSL5-deficient mice display an alteration in glucose homeostasis and an impaired fertility. Endocrinology. 2012 Oct;153(10):4655-65
• All: 1 reference(s)