Trpt1^tm1Dron
Targeted Allele Detail

Summary

• Symbol: Trpt1^tm1Dron
• Name: tRNA phosphotransferase 1; targeted mutation 1, David Ron
• MGI ID: MGI:5445769
• Gene: Trpt1 Location: Chr19:6973499-6976414 bp, + strand Genetic Position: Chr19, 5.13 cM
• Alliance: Trpt1^tm1Dron page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189412
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exons 3 through 5. Western blot analysis confirmed the absence of protein expression in the heart. (J:189412)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpt1 Mutation: 13 strains or lines available

References

• Original: J:189412 Harding HP, et al., An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation. RNA. 2008 Feb;14(2):225-32
• All: 1 reference(s)