Abcb10^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Abcb10^tm1Lex
• Name: ATP-binding cassette, sub-family B member 10; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5445808
• Synonyms: ABC-me^-
• Gene: Abcb10 Location: Chr8:124679198-124709861 bp, - strand Genetic Position: Chr8, 72.31 cM
• Alliance: Abcb10^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189396
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ/neo cassette replaced exon 2 and 3. Western blot analysis confirmed the absence of protein expression in embryos. (J:189396)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abcb10 Mutation: 42 strains or lines available

References

• Original: J:189396 Liesa M, et al., Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16;124(7):806-13
• All: 3 reference(s)