Scn5a^{tm4(SCN5A)Rdn}
Targeted Allele Detail

Summary

• Symbol: Scn5a^{tm4(SCN5A)Rdn}
• Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 4, Dan M Roden
• MGI ID: MGI:5445934
• Synonyms: FG
• Gene: Scn5a Location: Chr9:119312474-119408082 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Scn5a^{tm4(SCN5A)Rdn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189389
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, RMCE-ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Recombinase-mediated cassette exchange was used to replace exon 2 with a loxP site, the full-length and FLAG-tagged human SCN5A, an FRT-flanked hygro cassette and a loxP site. (J:189389)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn5a Mutation: 105 strains or lines available

References

• Original: J:189389 Watanabe H, et al., Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation. 2011 Aug 30;124(9):1001-11
• All: 1 reference(s)