Klb^tm1.1Sakl
Targeted Allele Detail

Summary

• Symbol: Klb^tm1.1Sakl
• Name: klotho beta; targeted mutation 1.1, Steven A Kliewer
• MGI ID: MGI:5446140
• Synonyms: Klb^fl
• Gene: Klb Location: Chr5:65505657-65541350 bp, + strand Genetic Position: Chr5, 33.64 cM
• Alliance: Klb^tm1.1Sakl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189018
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:189018)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klb Mutation: 58 strains or lines available

References

• Original: J:189018 Ding X, et al., betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab. 2012 Sep 5;16(3):387-93
• All: 24 reference(s)