Klb^tm1.2Sakl
Targeted Allele Detail

Summary

• Symbol: Klb^tm1.2Sakl
• Name: klotho beta; targeted mutation 1.2, Steven A Kliewer
• MGI ID: MGI:5446141
• Gene: Klb Location: Chr5:65505657-65541350 bp, + strand Genetic Position: Chr5, 33.64 cM
• Alliance: Klb^tm1.2Sakl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189018
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 1 and left the neo cassette intact. Western blot anlaysis confirmed the absence of protein in the brown adipose tissue, epididymal white adipose tissue and liver. (J:189018)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klb Mutation: 58 strains or lines available

References

• Original: J:189018 Ding X, et al., betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab. 2012 Sep 5;16(3):387-93
• All: 5 reference(s)