b2b999Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b999Clo
• Name: Mutant line 999; Bench to Bassinet Program (B2B/CVDC), mutation 999 Cecilia Lo
• MGI ID: MGI:5446155
• Synonyms: Comet
• Gene: b2b999Clo Location: unknown
• Alliance: b2b999Clo page

Mutant 999-006-1 (E17.5) exhibits hypoplastic pulmonary artery with evidence of ventricular hypertrophy

Show the 16 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b999Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiovascular phenotype: Semilunar valve dysplasia with pulmonary stenosis, tricuspid/mitral valve abnormalities observed by fetal echocardiography, ventricular hypertrophy

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
1508	Mitral valve abnormality
1610	Pulmonary stenosis
1700	Tricuspid valve abnormality
7504	Biventricular hypertrophy

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)