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b2b1835Clo
Chemically induced Allele Detail
Summary
Symbol: b2b1835Clo
Name: Mutant line 1835; Bench to Bassinet Program (B2B/CVDC), mutation 1835 Cecilia Lo
MGI ID: MGI:5446160
Synonyms: Sponge
Gene: b2b1835Clo  Location: unknown  
Alliance: b2b1835Clo page
Mutant 1835-006-3 (E15.5) shows a malpositioning of the pulmonary outflow which is confirmed by finding of overriding aorta by EFIC histology

Show the 9 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
    This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, b2b1835Clo, and may be present in stocks carrying this mutation.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b1835Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Cardiac phenotype: Double outlet right ventricle (DORV)/Overriding aorta (Ao), ventricular noncompaction, muscular VSD, atrioventricular septal defect, dysplastic semilunar valves

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0600 Double outlet right ventricle
1100 Atrioventricular canal (endocardial cushion defect)
1432 Overriding aortic valve
1849 Cardiomyopathy, left ventricular noncompaction

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory