b2b1854Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b1854Clo
• Name: Mutant line 1854; Bench to Bassinet Program (B2B/CVDC), mutation 1854 Cecilia Lo
• MGI ID: MGI:5446161
• Synonyms: Arctic
• Gene: b2b1854Clo Location: unknown
• Alliance: b2b1854Clo page

Mutant 1854-007-1 (E14.5) exhibits possible truncus arteriosus with interrupted aortic arch

Show the 9 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. Additional incidental mutations were detected in sequencing for the causative mutation, b2b1854Clo, and may be present in stocks carrying this mutation.

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b1854Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis: Cardiac phenotype: Persistant truncus arteriosus (PTA), double outlet right ventricle (DORV)
Noncardiac phenotype: Cleft palate, facial cleft, micrognathia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0541	Truncus arteriosus type 4a
0600	Double outlet right ventricle
4875	Cleft lip
4876	Cleft palate

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)