Cd22^{tm1.1(CD22)Lnit}
Targeted Allele Detail

Summary

• Symbol: Cd22^{tm1.1(CD22)Lnit}
• Name: CD22 antigen; targeted mutation 1.1, Lars Nitschke
• MGI ID: MGI:5446371
• Synonyms: Huki CD22
• Gene: Cd22 Location: Chr7:30564829-30579767 bp, - strand Genetic Position: Chr7, 19.26 cM
• Alliance: Cd22^{tm1.1(CD22)Lnit} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189017
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The human cDNA was inserted into exon 4. Cre-mediated recombination removed the downstream floxed neo cassette. Western blot analysis confirmed the absence of murine protein expression in B cells. (J:189017)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd22 Mutation: 64 strains or lines available

References

• Original: J:189017 Wohner M, et al., Human CD22 cannot fully substitute murine CD22 functions in vivo, as shown in a new knockin mouse model. Eur J Immunol. 2012 Nov;42(11):3009-18
• All: 3 reference(s)