Gpr89^tm1.1Ymae
Targeted Allele Detail

Summary

• Symbol: Gpr89^tm1.1Ymae
• Name: G protein-coupled receptor 89; targeted mutation 1.1, Yusuke Maeda
• MGI ID: MGI:5446388
• Synonyms: GPHR^f, GPHR^flox
• Gene: Gpr89 Location: Chr3:96775630-96812662 bp, - strand Genetic Position: Chr3, 42.01 cM, cytoband F2
• Alliance: Gpr89^tm1.1Ymae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189574
• Parent Cell Line: EGR-G01 (ES Cell)
• Strain of Origin: (129S2/SvPas x C57BL/6NSlc)F1-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exons 4 and 5 floxed. (J:189574)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr89 Mutation: 36 strains or lines available

References

• Original: J:189574 Tarutani M, et al., GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier. J Invest Dermatol. 2012 Aug;132(8):2019-25
• All: 2 reference(s)