Yap1^tm1.1Eno
Targeted Allele Detail

Summary

• Symbol: Yap1^tm1.1Eno
• Name: yes-associated protein 1; targeted mutation 1.1, Eric N Olson
• MGI ID: MGI:5446483
• Synonyms: Yap^fl
• Gene: Yap1 Location: Chr9:7932000-8004597 bp, - strand Genetic Position: Chr9, 2.46 cM
• Alliance: Yap1^tm1.1Eno page

Lethal cardiomyopathy in Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was inserted in intron 2 while an FRT flanked PGK-neo selection cassette followed by a second loxP site was inserted in intron 3. Subsequent excision of the selection cassette left exon 3 flanked by loxP sites. (J:189577)

Expression

In Mice Carrying this Mutation:	314 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Yap1 Mutation: 38 strains or lines available

References

• Original: J:189577 Xin M, et al., Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal. 2011;4(196):ra70
• All: 94 reference(s)