Zfhx3^tm1.2Jtd
Targeted Allele Detail

Summary

• Symbol: Zfhx3^tm1.2Jtd
• Name: zinc finger homeobox 3; targeted mutation 1.2, Jin-Tang Dong
• MGI ID: MGI:5446506
• Synonyms: Atbf1^delta7and8
• Gene: Zfhx3 Location: Chr8:109005975-109688272 bp, + strand Genetic Position: Chr8, 56.02 cM, cytoband E1
• Alliance: Zfhx3^tm1.2Jtd page

Reduced body size of Zfhx3^tm1.2Jtd/Zfhx3⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189563
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed the neo cassette, exon 7 and exon 8. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts following treatment with a cre-expressing adenovirus. (J:189563)

Generation of the Zfhx3^tm1.2Jtd allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfhx3 Mutation: 130 strains or lines available

References

• Original: J:189563 Sun X, et al., Heterozygous deletion of Atbf1 by the Cre-loxP system in mice causes preweaning mortality. Genesis. 2012 Nov;50(11):819-27
• All: 1 reference(s)