Cacna1c^tm1Ggm
Targeted Allele Detail

Summary

• Symbol: Cacna1c^tm1Ggm
• Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1, Geoffrey G Murphy
• MGI ID: MGI:5446616
• Synonyms: Cav1.2^f
• Gene: Cacna1c Location: Chr6:118564201-119173851 bp, - strand Genetic Position: Chr6, 55.86 cM
• Alliance: Cacna1c^tm1Ggm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189578
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and a floxed neo cassette was inserted into intron 2 via homologous recombination. (J:189578)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1c Mutation: 144 strains or lines available

References

• Original: J:189578 White JA, et al., Conditional forebrain deletion of the L-type calcium channel Ca V 1.2 disrupts remote spatial memories in mice. Learn Mem. 2008 Jan;15(1):1-5
• All: 8 reference(s)