Tg(Vav1-Lin28b)C3Apla
Transgene Detail

Summary

• Symbol: Tg(Vav1-Lin28b)C3Apla
• Name: transgene insertion C3, Peter Aplan
• MGI ID: MGI:5446657
• Transgene: Tg(Vav1-Lin28b)C3Apla Location: unknown
• Alliance: Tg(Vav1-Lin28b)C3Apla page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Vav1-Lin28b)C3Apla expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lin28b (MGI:3584032)

• Mutation details: The murine Lin28b cDNA was inserted into the HS 21/45-vav vector containing 3' and 5' Vav1-regulatory elements. The Vav1-regulatory elements target expression of Lin28b to hematopoietic tissues. Transgenic mRNA is expressed in the bone marrow, spleen and thymus. Three lines were made, C3, D4, and D10. (J:189197)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) (J:189197).

References

• Original: J:189197 Beachy SH, et al., Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma. Blood. 2012 Aug 2;120(5):1048-59
• All: 1 reference(s)