Il22ra2^tm2Vlcg
Targeted Allele Detail

Summary

• Symbol: Il22ra2^tm2Vlcg
• Name: interleukin 22 receptor, alpha 2; targeted mutation 2, Velocigene
• MGI ID: MGI:5446694
• Synonyms: VG437
• Gene: Il22ra2 Location: Chr10:19497776-19510429 bp, + strand Genetic Position: Chr10, 8.52 cM
• Alliance: Il22ra2^tm2Vlcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189217
• Parent Cell Line: VGF1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 9.4 kb fragment of the gene, extending from a position 7 amino acids downstream from the signal sequence into the 3' untranslated region, was replaced with a transmembrane-lacZ floxed neo cassette. (J:189217)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il22ra2 Mutation: 23 strains or lines available

References

• Original: J:189217 Huber S, et al., IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012 Nov 8;491(7423):259-63
• All: 5 reference(s)