Neu3^tm1Yamk
Targeted Allele Detail

Summary

• Symbol: Neu3^tm1Yamk
• Name: neuraminidase 3; targeted mutation 1, Kazunori Yamaguchi
• MGI ID: MGI:5446783
• Synonyms: Neu3^tm1Myg
• Gene: Neu3 Location: Chr7:99460646-99477579 bp, - strand Genetic Position: Chr7, 54.15 cM, cytoband F1
• Alliance: Neu3^tm1Yamk page

Decreased incidence of chemically induced colon tumors in Neu3^tm1Yamk/Neu3^tm1Yamk mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189604
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion A neo cassette replaced part of exon 3. RT-PCR confirmed the absence of transcript expression. (J:189604)

Generation of the Neu3^tm1Yamk allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neu3 Mutation: 25 strains or lines available

References

• Original: J:189604 Yamaguchi K, et al., Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase. PLoS One. 2012;7(7):e41132
• All: 12 reference(s)