Tcf21^tm1(cre)Seq
Targeted Allele Detail

Summary

• Symbol: Tcf21^tm1(cre)Seq
• Name: transcription factor 21; targeted mutation 1, Susan E Quaggin
• MGI ID: MGI:5446790
• Synonyms: Tcf21/Pod1-Cre
• Gene: Tcf21 Location: Chr10:22693162-22696042 bp, - strand Genetic Position: Chr10, 10.33 cM
• Alliance: Tcf21^tm1(cre)Seq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189643
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Tcf21^tm1(cre)Seq expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tcf21 (MGI:1202715)

• Mutation details: by homologous recombination in ES cells, exon 1 of the Tcf21 gene was replaced with a cassette encoding a nuclear localized cre recombinase, neomycin selection cassette and beta-actin polyadenylation sequence. One ES cell line produced chimeras that gave germline transmission of the allele. (J:189643)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tcf21 (mouse) Summary of all recombinase alleles driven by Tcf21. Alliance mouse Tcf21 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf21 Mutation: 16 strains or lines available

References

• Original: J:189643 Maezawa Y, et al., A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme. PLoS One. 2012;7(7):e40547
• All: 2 reference(s)