Glp2r^tm1.1Xfg
Targeted Allele Detail

Summary

• Symbol: Glp2r^tm1.1Xfg
• Name: glucagon-like peptide 2 receptor; targeted mutation 1.1, Xinfu Guan
• MGI ID: MGI:5446802
• Synonyms: Glp2r^fl
• Gene: Glp2r Location: Chr11:67554877-67661979 bp, - strand Genetic Position: Chr11, 41.13 cM
• Alliance: Glp2r^tm1.1Xfg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189593
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:189593)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Glp2r^tm1.1Xfg/Glp2r^tm1.1Xfg Tg(Pomc1-cre)16Lowl/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Phenotypes:

Affected Systems	cn1
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adipose tissue	√
increased percent body fat/body weight	√
behavior/neurological	√
increased eating frequency	√
increased food intake	√
increased vertical activity	√
digestive/alimentary system	√
abnormal gastrointestinal motility	√
growth/size/body	√
decreased lean body mass	√
obese	√
homeostasis/metabolism	√
increased oxygen consumption	√
abnormal metabolism	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glp2r Mutation: 39 strains or lines available

References

• Original: J:189593 Guan X, et al., GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. Am J Physiol Endocrinol Metab. 2012 Oct 1;303(7):E853-64
• All: 2 reference(s)