Glp2r^tm1.1Xfg
Targeted Allele Detail

Summary

• Symbol: Glp2r^tm1.1Xfg
• Name: glucagon-like peptide 2 receptor; targeted mutation 1.1, Xinfu Guan
• MGI ID: MGI:5446802
• Synonyms: Glp2r^fl
• Gene: Glp2r Location: Chr11:67554877-67661979 bp, - strand Genetic Position: Chr11, 41.13 cM
• Alliance: Glp2r^tm1.1Xfg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189593
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:189593)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glp2r Mutation: 39 strains or lines available

References

• Original: J:189593 Guan X, et al., GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. Am J Physiol Endocrinol Metab. 2012 Oct 1;303(7):E853-64
• All: 2 reference(s)