Del(Y)3H
Spontaneous Allele Detail
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Symbol: |
Del(Y)3H |
Name: |
deletion, Chr Y, 3 Harwell |
MGI ID: |
MGI:5446813 |
Synonyms: |
Yd, Yd-3, Yd3 |
Gene: |
Del(Y)3H Location: unknown Genetic Position: ChrY, Syntenic
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Strain of Origin: |
C57BL/6JHCt and RIII
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Allele Type: |
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Spontaneous |
Mutation: |
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Intergenic deletion
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Del(Y)3H involves 1 genes/genome features (Rbmyc)
View all
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Mutation details: This Y Chromosome (Chr) deletion resulted from asymmetric recombination between the short arm of a Y Chr (Yp) of C57BL/6 origin and an X Chr carrying Tp(Y)1CtSxr-a. Whereas Sry (sex determining region of Chr Y) and 16 other single-copy genes and pseudogenes on Yp appear intact by Southern blot analysis, all except a few copies of the Rbmy (RNA binding motif protein, Y Chr) repeat sequence family, which resides between Sry and the centromere and normally comprises at least 50 copies, have been deleted. Sry transcript levels in genital ridges of 11.5 day post coitus (dpc) XXYDel(Y)3H embryos are detectable at much lower levels than in XY embyos; in contrast, transcripts from Kdm5d, which maps distal to Sry between Zfy1 and Zfy2, are similarly abundant in XYDel(Y)3H and XY 11.5 dpc genital ridges.
(J:15425, J:29526)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Del(Y)3H Mutation: |
0 strains or lines available
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Original: |
J:15425 Capel B, et al., Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. Nat Genet. 1993 Nov;5(3):301-7 |
All: |
3 reference(s) |
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