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Del(Y)3H
Spontaneous Allele Detail
Summary
Symbol: Del(Y)3H
Name: deletion, Chr Y, 3 Harwell
MGI ID: MGI:5446813
Synonyms: Yd, Yd-3, Yd3
Gene: Del(Y)3H  Location: unknown  Genetic Position: ChrY, Syntenic
Mutation
origin
Strain of Origin:  C57BL/6JHCt and RIII
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intergenic deletion
  Del(Y)3H involves 1 genes/genome features (Rbmyc) View all
 
Mutation detailsThis Y Chromosome (Chr) deletion resulted from asymmetric recombination between the short arm of a Y Chr (Yp) of C57BL/6 origin and an X Chr carrying Tp(Y)1CtSxr-a. Whereas Sry (sex determining region of Chr Y) and 16 other single-copy genes and pseudogenes on Yp appear intact by Southern blot analysis, all except a few copies of the Rbmy (RNA binding motif protein, Y Chr) repeat sequence family, which resides between Sry and the centromere and normally comprises at least 50 copies, have been deleted. Sry transcript levels in genital ridges of 11.5 day post coitus (dpc) XXYDel(Y)3H embryos are detectable at much lower levels than in XY embyos; in contrast, transcripts from Kdm5d, which maps distal to Sry between Zfy1 and Zfy2, are similarly abundant in XYDel(Y)3H and XY 11.5 dpc genital ridges. (J:15425, J:29526)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(Y)3H Mutation:  0 strains or lines available
References
Original:  J:15425 Capel B, et al., Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. Nat Genet. 1993 Nov;5(3):301-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory