Mdm2^tm3.1Snj
Targeted Allele Detail

Summary

• Symbol: Mdm2^tm3.1Snj
• Name: transformed mouse 3T3 cell double minute 2; targeted mutation 3.1, Steven N Jones
• MGI ID: MGI:5446922
• Synonyms: Mdm2^D
• Gene: Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
• Alliance: Mdm2^tm3.1Snj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189297
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions (tcc to gat) results in the amino acid substitution of aspartic acid for serine at position 394 (S394D). This mutation is predicted to mimick a constitutively phsophorylated serine residue. Cre-mediated recombination removed the floxed neo cassette inserted downstream of exon 12. (J:189297)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mdm2^tm3.1Snj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm2 Mutation: 54 strains or lines available

References

• Original: J:189297 Gannon HS, et al., ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice. Cancer Cell. 2012 May 15;21(5):668-79
• All: 1 reference(s)