B3gnt6^tm1Lx
Targeted Allele Detail

Summary

• Symbol: B3gnt6^tm1Lx
• Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6; targeted mutation 1, Lijun Xia
• MGI ID: MGI:5447022
• Synonyms: C3GnT^-
• Gene: B3gnt6 Location: Chr7:97841622-97848682 bp, - strand Genetic Position: Chr7, 53.63 cM
• Alliance: B3gnt6^tm1Lx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123826
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ and neo cassette replaced exon 2. Enzymatic assay confirmed the absence of activity in the colon and ileum. (J:123826)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any B3gnt6 Mutation: 13 strains or lines available

References

• Original: J:123826 An G, et al., Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J Exp Med. 2007 Jun 11;204(6):1417-29
• All: 9 reference(s)