Tg(BCL2/IGH)#Jcre
Transgene Detail

Summary

• Symbol: Tg(BCL2/IGH)#Jcre
• Name: transgene insertion, John C Reed
• MGI ID: MGI:5447039
• Synonyms: BCL-2-tg
• Transgene: Tg(BCL2/IGH)#Jcre Location: unknown
• Alliance: Tg(BCL2/IGH)#Jcre page

Transgene origin

• Strain of Origin: (SWR/J x SJL/J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(BCL2/IGH)#Jcre expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

  human

  IGH (3492)
• Mutation details: A human genomic BCL2/IGH fusion minigene was used for the transgene. This construct represents a translocation mutation, t(14:18), found in human follicular B cell lymphomas. Line 2 (expression preferentially in the spleen, lymph nodes and thymus) and 6 (expression preferentially in the thymus, lymph node and spleen) were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:131936)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:131936 Katsumata M, et al., Differential effects of Bcl-2 on T and B cells in transgenic mice. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11376-80
• All: 8 reference(s)