Tg(Neurod2-Smo*A2)#Jols
Transgene Detail

Summary

• Symbol: Tg(Neurod2-Smo*A2)#Jols
• Name: transgene insertion, James M Olson
• MGI ID: MGI:5447065
• Synonyms: ND2:SmoA2
• Transgene: Tg(Neurod2-Smo*A2)#Jols Location: unknown
• Alliance: Tg(Neurod2-Smo*A2)#Jols page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Neurod2-Smo*A2)#Jols expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Smo (MGI:108075)

• Mutation details: The ND2:SmoA2 transgene contains the entire mouse smoothened homolog (Drosophila) Smo gene, with the constitutively active point mutation SmoA2 (S537N), driven by the 1kb mouse neurogenic differentiation 2 (Neurod2) promoter. Four lines were generated (221, 222, 225 and 242). All lines exhibit a low level of transgene expression (4-, 1-, 3- and 2-fold, respectively for each line relative to wild-type levels). The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:93861)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93861 Hallahan AR, et al., The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res. 2004 Nov 1;64(21):7794-800
• All: 4 reference(s)