Negr1^tm1Mkes
Targeted Allele Detail

Summary

• Symbol: Negr1^tm1Mkes
• Name: neuronal growth regulator 1; targeted mutation 1, Michael KE Schafer
• MGI ID: MGI:5447397
• Gene: Negr1 Location: Chr3:156267431-157022082 bp, + strand Genetic Position: Chr3, 80.6 cM
• Alliance: Negr1^tm1Mkes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189719
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion A neo cassette replaced exon 2. Western blot analysis confirmed the absence of protein expression. (J:189719)

Generation of the Negr1^tm1Mkes allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Negr1 Mutation: 33 strains or lines available

References

• Original: J:189719 Lee AW, et al., Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype. PLoS One. 2012;7(7):e41537
• All: 5 reference(s)