Negr1^m1H
Chemically induced Allele Detail

Summary

• Symbol: Negr1^m1H
• Name: neuronal growth regulator 1; mutation 1 Harwell
• MGI ID: MGI:5447400
• Synonyms: Negr1-I87N
• Gene: Negr1 Location: Chr3:156267431-157022082 bp, + strand Genetic Position: Chr3, 80.6 cM
• Alliance: Negr1^m1H page

Mutation origin

• Strain of Origin: (BALB/c x C3H/HeH)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A point mutation (T260A) that results in the amino acid substitution of asparagine for isoleucine at position 87 (I87N). Western blot analysis confirmed the absence of protein expression. (J:93069, J:189719)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Negr1 Mutation: 33 strains or lines available

References

• Original: J:189719 Lee AW, et al., Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype. PLoS One. 2012;7(7):e41537
• All: 2 reference(s)