Myc^{tm1.1(MYC)Gwbk}
Targeted Allele Detail

Summary

• Symbol: Myc^{tm1.1(MYC)Gwbk}
• Name: myelocytomatosis oncogene; targeted mutation 1.1, Georg W Bornkamm
• MGI ID: MGI:5447463
• Synonyms: hc-Myc
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^{tm1.1(MYC)Gwbk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189677
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted Mutations: Insertion, Intragenic deletion Mutation details: Sequence between the first translation start site (CUG) in exon 1 and the translation termination site (TAA) in exon 3 was replaced with the corresponding human sequence. Flp-mediated recombination removed a floxed neo cassette inserted into intron 2. The insertion produces a humanized Myc. (J:189677)

Generation of the Myc^tm1.1(MYC)Gwbk allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 43 strains or lines available

Notes

Humanized Myc

References

• Original: J:189677 Lehmann FM, et al., Humanized c-Myc mouse. PLoS One. 2012;7(7):e42021
• All: 1 reference(s)