Nr3c1^tm1.1Jda
Targeted Allele Detail

Summary

• Symbol: Nr3c1^tm1.1Jda
• Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 1.1, Jonathan D Ashwell
• MGI ID: MGI:5447468
• Synonyms: GR^fl
• Gene: Nr3c1 Location: Chr18:39543598-39652474 bp, - strand Genetic Position: Chr18, 21.09 cM
• Alliance: Nr3c1^tm1.1Jda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189951
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 and C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 3 and a second loxP site downstream of exon 3, followed by a frt-flanked neomycin resistance (neo) cassette. Flp-mediated recombination remvoed the neo cassette. (J:189951)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr3c1 Mutation: 35 strains or lines available

References

• Original: J:189951 Mittelstadt PR, et al., Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness. J Clin Invest. 2012 Jul 2;122(7):2384-94
• All: 40 reference(s)