Gt(ROSA)26Sor^tm1(Pyy)Paba
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(Pyy)Paba
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Paul A Baldock
• MGI ID: MGI:5447471
• Synonyms: PYY^lox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(Pyy)Paba page

Lower bone mass and reduced bone size in Gt(ROSA)26Sor^tm1(Pyy)Paba/Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} females

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189512
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm1(Pyy)Paba expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pyy (MGI:99924)

• Mutation details: A construct containing a CMV promoter, a floxed lacZ and neo cassette and a Pyy gene. Cre mediated recombination results in overexpression of PYY. (J:189512)

Schematic diagram of the Gt(ROSA)26Sor^tm1(Pyy)Paba transgene construct

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:189512 Wong IP, et al., Peptide YY regulates bone remodeling in mice: a link between gut and skeletal biology. PLoS One. 2012;7(7):e40038
• All: 1 reference(s)