Scn1a^tm2.1Wac
Targeted Allele Detail

Summary

• Symbol: Scn1a^tm2.1Wac
• Name: sodium channel, voltage-gated, type I, alpha; targeted mutation 2.1, William A Catterall
• MGI ID: MGI:5447489
• Gene: Scn1a Location: Chr2:66101125-66271181 bp, - strand Genetic Position: Chr2, 39.13 cM
• Alliance: Scn1a^tm2.1Wac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189897
• Parent Cell Line: REK2 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 25 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 25 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:189897)

Schematic representation of the targeting construct used to generate the Scn1a^tm2.1Wac allele

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scn1a Mutation: 114 strains or lines available

References

• Original: J:189897 Cheah CS, et al., Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14646-51
• All: 9 reference(s)