Lep^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lep^m1Btlr
• Name: leptin; mutation 1, Bruce Beutler
• MGI ID: MGI:5447548
• Synonyms: Potbelly
• Gene: Lep Location: Chr6:29060220-29073875 bp, + strand Genetic Position: Chr6, 12.3 cM
• Alliance: Lep^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU-induced a T to A transversion at position 21 in exon 2 of 3 total exons. The mutation results in a conversion of cysteine 7 to a premature stop codon within the N-terminal signal peptide region. (J:189953)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lep Mutation: 21 strains or lines available

References

• Original: J:189953 Beutler B, Direct Data Submission. MGI Direct Data Submission. 2012;v
• All: 1 reference(s)