Ptch1^tm1.1Hahn
Targeted Allele Detail

Summary

• Symbol: Ptch1^tm1.1Hahn
• Name: patched 1; targeted mutation 1.1, Heidi Hahn
• MGI ID: MGI:5447563
• Synonyms: Ptch^del
• Gene: Ptch1 Location: Chr13:63656142-63721274 bp, - strand Genetic Position: Chr13, 32.8 cM
• Alliance: Ptch1^tm1.1Hahn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149148
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 7 and a second loxP site followed by a frt-flanked neo cassette was inserted into intron 9. Cre-mediated recombination remvoed exons 8 and 9. (J:149148)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptch1^tm1.1Hahn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptch1 Mutation: 115 strains or lines available

References

• Original: J:149148 Zibat A, et al., Time-point and dosage of gene inactivation determine the tumor spectrum in conditional Ptch knockouts. Carcinogenesis. 2009 Jun;30(6):918-26
• All: 3 reference(s)