Atp7a^tm1.1Mjp
Targeted Allele Detail

Summary

• Symbol: Atp7a^tm1.1Mjp
• Name: ATPase, copper transporting, alpha polypeptide; targeted mutation 1.1, Michael J Petris
• MGI ID: MGI:5447640
• Synonyms: Atp7a^fl
• Gene: Atp7a Location: ChrX:105070882-105168532 bp, + strand Genetic Position: ChrX, 47.36 cM
• Alliance: Atp7a^tm1.1Mjp page

Patches of hypopigmentation in coats of Atp7a^tm1.1Mjp/Atp7a⁺ Cldn6^tm1(cre)Dkwu/Cldn6⁺ females

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 11. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exon 11 floxed. (J:189931)

Generation of the Atp7a^tm1.1Mjp allele

Disease models

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp7a Mutation: 69 strains or lines available

References

• Original: J:189931 Wang Y, et al., Conditional knockout of the Menkes disease copper transporter demonstrates its critical role in embryogenesis. PLoS One. 2012;7(8):e43039
• All: 6 reference(s)