Cd5^tm1.1Chra
Targeted Allele Detail

Summary

• Symbol: Cd5^tm1.1Chra
• Name: CD5 antigen; targeted mutation 1.1, Chander Raman
• MGI ID: MGI:5447646
• Synonyms: Cd5^deltack2bd
• Gene: Cd5 Location: Chr19:10695471-10716390 bp, - strand Genetic Position: Chr19, 7.16 cM
• Alliance: Cd5^tm1.1Chra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189919
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 10 was replaced with a floxed neo cassette and a modified exon 10 in which a microdeletion results in a selective inability to interact with CK2 (deletion of amino acids S458-S461). Cre-mediated recombination removed the neo cassette. (J:189919)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd5 Mutation: 36 strains or lines available

References

• Original: J:189919 Sestero CM, et al., CD5-dependent CK2 activation pathway regulates threshold for T cell anergy. J Immunol. 2012 Sep 15;189(6):2918-30
• All: 4 reference(s)